Alterations in tissue distribution of 99mTc-pertechnetate in rats given stannous tin.

Abstract

>A dose of 8 mg Sn(II)/kg produces significant mortality and gross kidney damage in the rat. The tissue distribution of /sup 99m/Tcpertechnetate is altered in rats that have previously received Sn(II). Minimal changes are noted with a dose of 0.02 mg Sn(II)/kg. It should be noted that most kits for human use contain less than 1 mg of Sn(II) per kit and result in a dose less than 0.007 mg Sn(II)/kg. Changes are still present 13 weeks after a dose of 8 mg Sn(II)/kg. It is apparent that the effects of Sn(II) on /sup 99m/Tc-pentechnetate are not limited to in vitro reaction. The alterations in tissue distribution of /sup 99/ Tc-pertechnetate are most likely due to the chemical reduction and fixation of the /sup 99/Tc-pertechnetate to tissue components due to the continuing presence of Sn(II) in vivo. (auth)