Concepedia

Extracellular cathepsin K exerts antimicrobial activity and is protective against chronic intestinal inflammation in mice

Christian Sina, Simone Lipinski, Olga Gavrilova, Konrad Aden, Ateequr Rehman, Andreas Till, Andrea Rittger, Rainer Podschun, Ulf Meyer‐Hoffert, Robert Haesler,

Gut · 2012 · 34 citations · 40 references

DOI

Abstract

These data identify extracellular cathepsin K as an intestinal antibacterial factor with anti-inflammatory potential and suggest that topical administration of cathepsin K might provide a therapeutic option for patients with inflammatory bowel disease.

References

40

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Kenneth J. Livak, Thomas D. Schmittgen · Methods · 2001 · 176.9K citations

, , +12

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

Malin Johansson, Mia Phillipson, Joel Petersson et al. · Proceedings of the National Academy of Sciences · 2008 · 2.1K citations · Full text

, , +14

Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease

S. Ott · Gut · 2004 · 1.3K citations · Full text

Enteric defensins are essential regulators of intestinal microbial ecology

Nita H. Salzman, Kuiechun Hung, Dipica Haribhai et al. · Nature Immunology · 2009 · 1.1K citations · Full text

, , +4

Pycnodysostosis, a Lysosomal Disease Caused by Cathepsin K Deficiency

Bruce D. Gelb, Guo‐Ping Shi, Harold A. Chapman et al. · Science · 1996 · 1K citations

, , +19