The Journals of Gerontology Series B · 1997 · 302 citations · 53 references
MedicineNeurologyNeuroscienceCognitive NeurologyDementiaGeriatric AssessmentAlzheimer DiseaseCognitive AgingCognitive AssessmentCognitive DeclineCognitive ImpairmentMotor Function AssessmentCognitive Impairment EvaluationCognitive Motor AssessmentDexterity AssessmentGeriatric Cognitive AssessmentKinematic DexterityMotor Behavior AssessmentMotor Impairment AssessmentMotor-cognitive Interaction
In order to determine the relationship between cognitive dysfunction and motor behavior in older adults, 41 cognitively normal elderly (NL), 25 cases exhibiting mild cognitive impairment (MI), and 25 patients with mild Alzheimer's disease (AD) were examined using a broad array to motor/psychomotor and cognitive tests. Relative to the NL group, MI individuals (at risk for future decline to AD) performed worse on tasks involving fine and complex motor function (e.g., tracking and manual dexterity). AD patients also exhibited motor dysfunction on tasks assessing relatively more rudimentary motor control. Motor tasks were able to distinguish NL vs MI and NL vs mild AD individuals as effectively as cognitive tests of memory and language. These results indicate that motor impairment is an important aspect of cognitive decline in older adults. Motor/psychomotor assessments may be comparably sensitive to traditional tests of cognitive function in identifying persons affected by the earliest stages of AD pathology.
53
Clinical diagnosis of Alzheimer's disease
Guy M. McKhann, David A. Drachman, Marshall Folstein et al. · Neurology · 1984 · 28K citations · Full text
A New Clinical Scale for the Staging of Dementia
Charles P. Hughes, Leonard van den Berg, Warren L. Danziger et al. · The British Journal of Psychiatry · 1982 · 7K citations