Testosterone-mediated modulation of HERG blockade by proarrhythmic agents11Abbreviations: TdP, torsades de pointes; HERG, human ether-a-go-go related gene; DMSO, dimethyl sulfoxide.

A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel

Michael C. Sanguinetti, Changan Jiang, Mark Curran et al. · Cell · 1995 · 2.4K citations · Full text

Medicine, Cardiology, Molecular Genetics +16

Coassembly of KVLQT1 and minK (IsK) proteins to form cardiac IKS potassium channel

Michael C. Sanguinetti, Mark Curran, Anruo Zou et al. · Nature · 1996 · 1.8K citations

Natural Sciences, Biochemistry, Molecular Biology +12

Antipsychotic drug doses and neuroleptic/dopamine receptors

Philip Seeman, T. Lee, M. Chau-Wong et al. · Nature · 1976 · 1.6K citations

Medicine, Pharmacology, Psychiatry +13

KvLQT1 and IsK (minK) proteins associate to form the IKS cardiac potassium current

Jacques Barhanin, Florian Lesage, Eric Guillemare et al. · Nature · 1996 · 1.6K citations

Natural Sciences, Molecular Biology, Physiology +12

MiRP1 Forms IKr Potassium Channels with HERG and Is Associated with Cardiac Arrhythmia

Geoffrey W. Abbott, Federico Sesti, Igor Splawski et al. · Cell · 1999 · 1.4K citations · Full text

Medicine, Cardiology, Molecular Genetics +17