Concepedia

Contribution of reactive oxygen species to pathways of quinolone-mediated bacterial cell death

Xiqing Wang, Xilin Zhao, Muhammad Malik, Karl Drlica

Journal of Antimicrobial Chemotherapy · 2010 · 140 citations · 10 references

DOI

Abstract

Inhibitor studies indicated that hydroxyl radical action contributes to quinolone-mediated cell death occurring via the chloramphenicol-sensitive lethal pathway but not via the chloramphenicol-insensitive pathway.

References

10

A Common Mechanism of Cellular Death Induced by Bactericidal Antibiotics

Michael A. Kohanski, Daniel J. Dwyer, Boris Hayete et al. · Cell · 2007 · 2.9K citations · Full text

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Development of Novel Fluorescence Probes That Can Reliably Detect Reactive Oxygen Species and Distinguish Specific Species

Ken‐ichi Setsukinai, Yasuteru Urano, Katsuko Kakinuma et al. · Journal of Biological Chemistry · 2003 · 1.3K citations · Full text

Mistranslation of Membrane Proteins and Two-Component System Activation Trigger Antibiotic-Mediated Cell Death

Michael A. Kohanski, Daniel J. Dwyer, Jamey Wierzbowski et al. · Cell · 2008 · 557 citations · Full text

, , +8

Gyrase inhibitors induce an oxidative damage cellular death pathway in <i>Escherichia coli</i>

Daniel J. Dwyer, Michael A. Kohanski, Boris Hayete et al. · Molecular Systems Biology · 2007 · 461 citations · Full text

Escherichia coli DNA topoisomerase I mutants have compensatory mutations in DNA gyrase genes

Stephen DiNardo, K Voelkel, Rolf Sternglanz et al. · Cell · 1982 · 444 citations

, , +10