Concepedia

Genomic and epigenetic evidence for oxytocin receptor deficiency in autism

Simon G. Gregory, Jessica J. Connelly, Aaron J. Towers, Jessica Johnson, Dhani Biscocho, Christina A. Markunas, Carla Lintas, Ruth K. Abramson, Harry H. Wright, Peter Ellis,

BMC Medicine · 2009 · 571 citations · 66 references

DOIFull text

Open access

Abstract

Together, these data provide further evidence for the role of OXTR and the oxytocin signaling pathway in the etiology of autism and, for the first time, implicate the epigenetic regulation of OXTR in the development of the disorder.See the related commentary by Gurrieri and Neri: http://www.biomedcentral.com/1741-7015/7/63.

References

66

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Kenneth J. Livak, Thomas D. Schmittgen · Methods · 2001 · 176.9K citations

, , +12

Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders

Catherine Lord, Michael Rutter, Ann Le Couteur · Journal of Autism and Developmental Disorders · 1994 · 8.9K citations

, , +9

Epigenetic programming by maternal behavior

Ian C.G. Weaver, Nadia Cervoni, Frances A. Champagne et al. · Nature Neuroscience · 2004 · 6.1K citations

, , +4

Detection of large-scale variation in the human genome

A. John Iafrate, Lars Feuk, Miguel N. Rivera et al. · Nature Genetics · 2004 · 2.9K citations

, , +8

Strong Association of De Novo Copy Number Mutations with Autism

Jonathan Sebat, B. Lakshmi, Dheeraj Malhotra et al. · Science · 2007 · 2.8K citations · Full text

, , +13