Removal of the conserved disulfide bridges from the scfv fragment of an antibody: effects on folding kinetics and aggregation

Evidence for a three-state model of protein folding from kinetic analysis of ubiquitin variants with altered core residues

Sepideh Khorasanizadeh, Iain D. Peters, Heinrich Röder · Nature Structural Biology · 1996 · 347 citations

Life Sciences, Biochemistry, Molecular Biology +17

Antibody scFv fragments without disulfide bonds, made by molecular evolution

Karl Proba, Arne Wörn, Annemarie Honegger et al. · Journal of Molecular Biology · 1998 · 239 citations

Pharmacy, Biochemistry, Molecular Biology +11

The disulfide bonds in antibody variable domains: effects on stability, folding in vitro, and functional expression in Escherichia coli

Rudi Glockshuber, Thomas G.M. Schmidt, A. Plueckthun · Biochemistry · 1992 · 195 citations

Life Sciences, Biochemistry, Molecular Biology +17

Fluorescence and protein structure

Robert W. Cowgill · Biochimica et Biophysica Acta (BBA) - Protein Structure · 1967 · 191 citations

Natural Sciences, Biochemistry, Biophysics +12

Fluorescence and protein structure

Robert W. Cowgill · Biochimica et Biophysica Acta (BBA) - Protein Structure · 1967 · 157 citations

Natural Sciences, Biochemistry, Biophysics +12