Synthesis, Preclinical Validation, Dosimetry, and Toxicity of <sup>68</sup>Ga-NOTA-Anti-HER2 Nanobodies for iPET Imaging of HER2 Receptor Expression in Cancer - Concepedia

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Synthesis, Preclinical Validation, Dosimetry, and Toxicity of <sup>68</sup>Ga-NOTA-Anti-HER2 Nanobodies for iPET Imaging of HER2 Receptor Expression in Cancer

DOI Full Paper Access

219

Citations

24

References

2013

Year

Catarina Xavier, Ilse Vaneycken, Matthias D’Huyvetter, Johannes Heemskerk, Marleen Keyaerts, Cécile Vincke, Nick Devoogdt, Serge Muyldermans, Tony Lahoutte, Vicky Caveliers

Journal of Nuclear Medicine

Abstract

A new anti-HER2 PET tracer, (68)Ga-NOTA-2Rs15d, was synthesized via a rapid procedure under mild conditions. Preclinical validation showed high-specific-contrast imaging of HER2-positive tumors with no observed toxicity. (68)Ga-NOTA-2Rs15d is ready for first-in-human clinical trials.

References

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