Functional variants of gene encoding folate metabolizing enzyme and methotrexate-related toxicity in children with acute lymphoblastic leukemia

Haploview: analysis and visualization of LD and haplotype maps

Jeffrey C. Barrett, Ben Fry, Julian Maller et al. · Bioinformatics · 2004 · 14.7K citations · Full text

Life Sciences, Biostatistics, Genetics +17

Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia

Joseph L. Wiemels, R. Smith, G. Malcolm Taylor et al. · Proceedings of the National Academy of Sciences · 2001 · 339 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

Methotrexate related adverse effects in patients with rheumatoid arthritis are associated with the A1298C polymorphism of the MTHFR gene

Yackov Berkun · Annals of the Rheumatic Diseases · 2004 · 172 citations · Full text

Medicine, Genetics, Pharmacology +15

Gene polymorphisms in folate metabolizing enzymes in adult acute lymphoblastic leukemia: effects on methotrexate-related toxicity and survival

Alessia Ongaro, Monica De Mattei, Matteo Giovanni Della Porta et al. · Haematologica · 2009 · 93 citations · Full text

Medicine, Biochemistry, Pharmacology +17

The pharmacogenetics of methotrexate in inflammatory bowel disease

Klaus Herrlinger, Fraser Cummings, Martin Barnardo et al. · Pharmacogenetics and Genomics · 2005 · 69 citations

Veterinary Medicine, Genetics, Pharmacology +17