Asymmetric Synthesis of Diarylmethyl Amines by Rhodium‐Catalyzed Asymmetric Addition of Aryl Titanium Reagents to Imines

Abstract

A rational tuning of the arene sulfonamide moiety (by introducing isopropyl groups onto the phenyl ring) brought about high enantioselectivity in the asymmetric synthesis of diarylmethyl amines by the title reaction (see scheme). Ar1=4-CF3C6H4, 4-ClC6H4, 4-FC6H4, 3-MeOC6H4, 4-MeOC6H4, 2-MeC6H4, 1-naphthyl, Ph; Ar2=Ph, 4-FC6H4, 3-MeOC6H4, 4-MeOC6H4.