Advanced Synthesis & Catalysis · 2001 · 456 citations · 0 references
Natural SciencesChemistryCatalysisOrganic ChemistryStructure-activity RelationshipsCatalyst DesignCatalyst SynthesisCoordination ChemistryHeterocyclic ChemistryLigand-based DesignMolecular SymmetryAsymmetric CatalysisAsymmetric Catalyst DesignChiral Catalyst DesignDihedral AngleHydrogenationHydrogenation CatalysisHydrogenation ReactionsLigand Design
A series of novel optically active diphosphine ligands, (4,4′-bi-1,3-benzodioxole)-5,5′-diylbis(diarylphosphine)s (6), which are called SEGPHOS, has been designed and synthesized with dihedral angles in the Ru complexes being less than that in the corresponding BINAP-Ru complex. The stereorecognition abilities of SEGPHOS-Ru complex catalysts in the asymmetric catalytic hydrogenation of a wide variety of carbonyl compounds are superior to those observed with BINAP-Ru complex catalysts.