Successful Treatment of Daptomycin-Nonsusceptible Methicillin-Resistant <i>Staphylococcus Aureus</i> Bacteremia with the Addition of Rifampin to Daptomycin

Abstract

In patients with persistent MRSA bacteremia, isolates should be retested for susceptibility to both daptomycin and vancomycin, including assessment for vancomycin heteroresistance. Addition of rifampin to daptomycin may be effective for persistent MRSA bacteremia, even if daptomycin MICs are elevated. Prospective studies are needed to define the role of combination therapy.