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Binding of acetylcholine and other molecular cations by a macrocyclic receptor molecule of speleand type
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1984
Year
Molecular BiologyOrganic ChemistryPrimary Ammonium CationsReceptor MoleculeChiral Tetracarboxylic MacrocycleMolecular RecognitionOther Molecular CationsSpeleand TypeBiochemistryMacrocyclic Receptor MoleculeG Protein-coupled ReceptorReceptor (Biochemistry)PharmacologyEnantioselective SynthesisSignal TransductionFunctional SelectivityNatural SciencesPhysiologyNeuropeptide ReceptorMedicineNeuropeptides
The chiral tetracarboxylic macrocycle (1) is a receptor molecule of the speleand type which binds strongly quaternary as well as primary ammonium cations, in particular acetylcholine and methylviologen.