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Genetic Mapping of the Locus Controlling Structural Variations of Murine C3 in the Chromosome 17
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1979
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GeneticsMolecular GeneticsGenomicsGenetic MappingBackcross ProgenyKnockout MouseGenome StructureGenetic VariationChromosomal RearrangementC3 AllotypeChromatinDevelopmental BiologyChromatin StructureGenetic DisorderMurine C3Genetic MechanismChromosome BiologyChromosome 17Mutant Gene TfMedicineChromosome 9
Backcross progeny, (NC X TF/GnLe)F1 X TF/GnLe, was tested for C3 allotype controlled by C3-1 and the expression of mutant gene tf, repeated loss and regrowth of hair. The recombination frequency between these two loci both located in chromosome 17 of the mouse was 24%. Taken together with our previous linkage data, C3-1 is now localized to a position 11 cm more distal than H-2 on chromosome 17.