Concepedia

Hyperglycaemia-induced cardiomyocyte death is mediated via MCP-1 production and induction of a novel zinc-finger protein MCPIP

Craig W. Younce, Kangkai Wang, Pappachan E. Kolattukudy

Cardiovascular Research · 2010 · 135 citations · 36 references

DOIFull text

Open access

Abstract

Glucose-induced cardiomyocyte death is mediated via MCP-1 production and MCPIP induction, which causes sequential events--ROS production, ER stress, autophagy, and cell death.

References

36

Global Burden of Diabetes, 1995–2025: Prevalence, numerical estimates, and projections

Hilary King, Ronald E. Aubert, William H. Herman · Diabetes Care · 1998 · 6.3K citations

Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy

Sophie Pattingre, Amina Tassa, Xueping Qu et al. · Cell · 2005 · 3.4K citations · Full text

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Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes

Umut Özcan, Erkan Yılmaz, Lale Özcan et al. · Science · 2006 · 2.4K citations · Full text

, , +21

Inhibition of Macroautophagy Triggers Apoptosis

Patricia Boya, Rosa A. González‐Polo, Noëlia Casares et al. · Molecular and Cellular Biology · 2005 · 1.6K citations · Full text

Absence of Monocyte Chemoattractant Protein-1 Reduces Atherosclerosis in Low Density Lipoprotein Receptor–Deficient Mice

Long Gu, Yoshikatsu Okada, Steven K. Clinton et al. · Molecular Cell · 1998 · 1.6K citations · Full text

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