Anti-proliferative and Apoptotic Effects of morin in human Leukemia cell lines (HUT-78)

Abstract

an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cancer is one of the main cause of mortality in the world which appears by the effect of enviromental physico-chemical mutagen and carcinogen agents. Lymphoblastic leukemia is one the prevalence cancer in human. Chemotherapy and radiotherapy improve remission of the disease but some probability relaps is observed between 20-30 % patients. Tumorgenesis and tumor progression are strongly associated with abnormal apoptosis. A number of natural antitumor drugs exert their therapeutic effect by inducing or promoting apoptosis [1]. In the last years, many studies have been performed on the anticancer effects of flavonoids. In cancer therapies, natural compounds have been considered as effective inhibitor agents. There is evidence to support the concept that 2`,3,4`,5,7 pentha hydroxyl flavone (morin) has a great potential to develop into novel cancer preventative agent [2]. Aim To investigate the effect of morin on apoptosis of human leukemia cells (Nalm-6 and HUT-78).