Cardiac metabolism in a new rat model of type 2 diabetes using high-fat diet with low dose streptozotocin

Positional cloning of the mouse obese gene and its human homologue

Yiying Zhang, Ricardo Proenca, Margherita Maffei et al. · Nature · 1994 · 13.3K citations

Obesity, Metabolic Syndrome, Knockout Mouse +10

THE GLUCOSE FATTY-ACID CYCLE ITS ROLE IN INSULIN SENSITIVITY AND THE METABOLIC DISTURBANCES OF DIABETES MELLITUS

P J Randle, P. B. Garland, C. N. Hales et al. · The Lancet · 1963 · 5.1K citations

Obesity, Metabolic Syndrome, Biochemistry +10

Abnormal splicing of the leptin receptor in diabetic mice

Gwo‐Hwa Lee, R Proenca, Jason Montez et al. · Nature · 1996 · 2.3K citations

Diabetes, Immunology, Hypothalamic Peptide +5

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

Hong Chen, Olga Charlat, Louis A. Tartaglia et al. · Cell · 1996 · 2.2K citations · Full text

Metabolic Syndrome, Neuropeptides, Systems Biology +10

Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: A model for type 2 diabetes and pharmacological screening

K. K. Srinivasan, Bhoomi Viswanad, Lydia Asrat et al. · Pharmacological Research · 2005 · 1.8K citations

Metabolic Syndrome, Diabetes Management, Medicine +9