Concepedia

Pharmacology of LY315920/S-5920, [[3-(Aminooxoacetyl)-2-ethyl-1-(phenylmethyl)-1 H-indol-4-yl]oxy]acetate, a Potent and Selective Secretory Phospholipase A2Inhibitor: A New Class of Anti-Inflammatory Drugs, SPI

David W. Snyder, Nicholas J. Bach, Robert D. Dillard, Susan E. Draheim, Donald G. Carlson, Niles Fox, Neal W. Roehm, Christopher T. Armstrong, Lawrence W. Hartley, Lea M. Johnson,

Journal of Pharmacology and Experimental Therapeutics · 1999 · 88 citations · 35 references

DOI

Concepts

References

35

Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.

Jaime L. Masferrer, Ben S. Zweifel, Pamela T. Manning et al. · Proceedings of the National Academy of Sciences · 1994 · 1.3K citations

, , +17

Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters.

J. M. van Rossum · PubMed · 1963 · 1.2K citations

, , +14

The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia

Melina MacPhee, Kenneth P. Chepenik, Rebecca A. Liddell et al. · Cell · 1995 · 565 citations · Full text

, , +10

Role of secretory phospholipases A2 in the pathobiology of disease.

Peter Vadas, W. Pruzanski · PubMed · 1986 · 382 citations

, , +9

A Natural Disruption of the Secretory Group II Phospholipase A2 Gene in Inbred Mouse Strains

Brian P. Kennedy, Paul Payette, John S. Mudgett et al. · Journal of Biological Chemistry · 1995 · 326 citations · Full text

, , +9