Quantitation of Orphenaorine Citrate and Acetaminophen In Tablet Formulation Using Thin Layer Chromatography Densitometry

Abstract

Abstract A thin layer chromatographic method for the quantitative determination of orphenadrine citrate and acetaminophen in tablet formulations was developed. the method involves direct application of methanolic tablet suspensions on silica gel plates. the eluent used for the development consisted of toluene, ethyl acetate, propylene glycol and acetic acid. Linearity and reproducibility were evaluated. Recovery of active ingredients from dosage forms was calculated. the method is simple and does not require sample manipulation prior to analysis. Key Words: Thin Layer ChromatographyDensitometryOrphenadrine CitrateAcetaminophenTablet Formulations.