Changes in cardiovascular health score and atherosclerosis progression in middle-aged and older persons in China: a cohort study

Abstract

OBJECTIVES: The American Heart Association (AHA) proposed a definition of 4 cardiovascular health behaviours and 3 health factors. On the basis of the 7 metrics, the cardiovascular health score (CHS) was used to estimate individual-level changes in cardiovascular health status. The aim of this study was to investigate whether changes in CHS (⊿CHS) at different time-points are associated with atherosclerosis progression in middle-aged and older persons. DESIGN: Prospective cohort study in China. SETTINGS: We defined 8 groups (≤-4, -3, -2, -1, 0, 1, 2 and ≥ 3) according to ⊿CHS. The impact of ⊿CHS on the change of brachial-ankle pulse wave velocity (⊿baPWV) and atherosclerosis progression was analysed. PARTICIPANTS: A total of 3951 individuals met the inclusion criteria (≥ 40 years old; no history of stroke, transient ischaemic attack or myocardial infarction) and had complete information. RESULTS: ⊿baPWV decreased gradually (126.46 ± 355.91, 78.4 ± 343.81, 69.6 ± 316.27, 49.59 ± 287.57, 57.07 ± 261.17, 40.45 ± 264.27, 37.45 ± 283.26 and 21.66 ± 264.17 cm/s, respectively) with increasing ⊿CHS (p for trend<0.05). Multivariate linear regression analysis suggested a negative relationship between these 2 variables, which persisted after adjustment for other risk factors. Each increase in CHS was associated with a reduced baPWV for 15.22 cm/s (B value -15.22, p<0.001). CONCLUSIONS: ⊿CHS were negatively related to ⊿baPWV, which proved to be an independent predictor of the progression of atherosclerosis in middle-aged and older persons. TRIAL REGISTRATION NUMBER: Kailuan study (ChiCTR-TNC-11001489).