Concepedia

Cognitive deficits following anti-NMDA receptor encephalitis

Carsten Finke, Ute A. Kopp, Josep Dalmau, Klaus‐Peter Wandinger, Christoph J. Ploner

Journal of Neurology Neurosurgery & Psychiatry · 2011 · 344 citations · 10 references

DOIFull text

Open access

Abstract

Our results suggest that cognitive deficits constitute a major long-term morbidity of anti-NMDAR encephalitis. These deficits relate to the distribution of NMDARs in the human brain and their functional role in normal cognition. Good cognitive long-term outcome may depend on early and aggressive treatment.

References

10

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

Richard Morris, Eric Anderson, Gary Lynch et al. · Nature · 1986 · 3.6K citations

, , +7

Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies

Josep Dalmau, Amy J. Gleichman, Ethan G. Hughes et al. · The Lancet Neurology · 2008 · 3.4K citations · Full text

, , +12

The Essential Role of Hippocampal CA1 NMDA Receptor–Dependent Synaptic Plasticity in Spatial Memory

Joe Z. Tsien, Patricio T. Huerta, Susumu Tonegawa · Cell · 1996 · 1.8K citations · Full text

, , +12

Requirement for Hippocampal CA3 NMDA Receptors in Associative Memory Recall

Kazu Nakazawa, Michael C. Quirk, Raymond A. Chitwood et al. · Science · 2002 · 1.1K citations · Full text

, , +18

N-methyl-d-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes

Sarosh R. Irani, Katarzyna D. Bera, Patrick Waters et al. · Brain · 2010 · 1K citations · Full text