Sphingosine kinase-1 is a downstream regulator of imatinib-induced apoptosis in chronic myeloid leukemia cells

Dasatinib in Imatinib-Resistant Philadelphia Chromosome–Positive Leukemias

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Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

Olivier Cuvillier, Grisha Pirianov, Burkhard Kleuser et al. · Nature · 1996 · 1.5K citations

Life Sciences, Biochemistry, Cell Biology +12

Nilotinib in Imatinib-Resistant CML and Philadelphia Chromosome–Positive ALL

Hagop M. Kantarjian, Francis J. Giles, Lydia Wunderle et al. · New England Journal of Medicine · 2006 · 1.3K citations · Full text

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Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: diverse mechanisms of resistance

François Xavier Mahon, Michael W. Deininger, Beate Schultheis et al. · Blood · 2000 · 760 citations

Medicine, Molecular Biology, Oncology +15

Activation of sphingosine kinase 1 by ERK1/2‐mediated phosphorylation

Stuart M. Pitson, Paul A.B. Moretti, Julia R. Zebol et al. · The EMBO Journal · 2003 · 537 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +12