International Journal of Pharmaceutics · 2008 · 78 citations · 7 references
EngineeringInformation SystemsModel-based Systems EngineeringProcess DesignSystems ModelingModel TransformationModel-driven DevelopmentModel-driven Software EngineeringProcess ArchitectureProcess EngineeringProcess ModelingGraph TransformationProcess Model TransformationProcess Modeling LanguagesProcess Modeling SemanticsTransformation Languages
Topiramate [2,3:4,5-bis-O-(1-methylethylidene) β-D-fructo-pyranose sulfamate] was found to form a new polymorphic form in the presence of polyethylene glycol 8000 (PEG). Comparative study of the solid state interactions of PEG and structural topiramate analogue lacking sulfamate group (Diacetone D-fructose) indicated that the sulfamate moiety was essential for the formation of the new polymorph. The drug-polymer interactions were investigated using differential s canning calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR) and hot stage microscopy. The new polymorphic form was characterized using variable temperature powder X-ray diffraction (VTPXRD) and solid state Nuclear Magnetic Resonance (ssNMR). The new polymorph was found to form only in the presence of PEG at specific weight ratios.
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Wil M. P. van der Aalst, Arthur H. M. ter Hofstede, Bartek Kiepuszewski et al. · Distributed and Parallel Databases · 2003 · 2.6K citations · Full text
YAWL: yet another workflow language
Wil M. P. van der Aalst, Arthur H. M. ter Hofstede · Information Systems · 2004 · 1.3K citations · Full text