MRI identification of the rostral‐caudal pattern of pathology within the corpus callosum in the cuprizone mouse model

Abstract

Noninvasive MRI using quantitative T2 and ADC mapping accurately characterized the rostral-caudal pattern of CC demyelination and other pathologies in cuprizone challenged mice, and thus could provide an effective way to assess the structural response to experimental therapeutics being designed for the treatment of MS.