HPV detection in primary intra‐oral squamous cell carcinomas – commensal, aetiological agent or contamination?

Abstract

We support the view that HPV is probably unimportant in the pathogenesis of OSCC and hypothesize HPV detection techniques as the main reason for the positive results in many studies. Real-time PCR was confirmed as the most sensitive technique, but researchers are urged to incorporate strict internal controls when using this detection method.