Bacterial Synthesis of Diverse Indole Terpene Alkaloids by an Unparalleled Cyclization Sequence

Abstract

Getting indole terpenes into shape: Genetic analysis, pathway dissection, and heterologous reconstitution provide first insights into bacterial indolosesquiterpenoid biosynthesis and unveil the involvement of a new type of terpene cyclase and an indole oxygenase in the formation of indosespene, xiamycin, and sespenine ring systems. Furthermore, heterologous pathway expression led to the discovery of CC- and CN-linked xiamycin dimers. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.