Bacterial frataxin CyaY is the gatekeeper of iron-sulfur cluster formation catalyzed by IscS

Friedreich's Ataxia: Autosomal Recessive Disease Caused by an Intronic GAA Triplet Repeat Expansion

Victoria Campuzano, Laura Montermini, María Dolores Moltó et al. · Science · 1996 · 2.8K citations

Life Sciences, Genetics, Molecular Genetics +17

Studies of human, mouse and yeast homologues indicate a mitochondrial function for frataxin

Hana Koutníková, Victoria Campuzano, Françoise Foury et al. · Nature Genetics · 1997 · 474 citations

Life Sciences, Genetics, Molecular Biology +11

IscR, an Fe-S cluster-containing transcription factor, represses expression of <i>Escherichia coli</i> genes encoding Fe-S cluster assembly proteins

Christopher Schwartz, Jennifer L. Giel, Thomas Patschkowski et al. · Proceedings of the National Academy of Sciences · 2001 · 427 citations · Full text

Life Sciences, Genetics, Molecular Biology +12

IscU as a Scaffold for Iron−Sulfur Cluster Biosynthesis:  Sequential Assembly of [2Fe-2S] and [4Fe-4S] Clusters in IscU

Jeffrey N. Agar, Carsten Krebs, Jeverson Frazzon et al. · Biochemistry · 2000 · 426 citations

Life Sciences, Biochemistry, Molecular Biology +16

A Human Mitochondrial Ferritin Encoded by an Intronless Gene

Sonia Levi, Barbara Corsi, Marta Bosisio et al. · Journal of Biological Chemistry · 2001 · 400 citations · Full text

Medicine, Genetics, Molecular Genetics +16