Cyclooligocondensation of Amino Acids: Macrocyclic Amides of β‐Alanine

Abstract

Nitrogen analogs of crown ethers of type (2) have recently atracted much attention. The reaction β‐alanine → (1) → (2) provides the simplest entry yet to these compounds. The tendency to form large rings in macrocyclization equilibria could be estimated for β‐alanine → (1) . equation image