Glucose Tolerance in Twin Pregnancy

Abstract

Summary: Over a 10‐year period, 50 g oral glucose tolerance tests were performed in 288 patients with twin pregnancies and 20,030 with singleton pregnancies. In multiple pregnancies the fasting blood glucose value was significantly reduced (P<0.001), but the values at 1, 2 and 3 hours were not significantly different from those in singleton pregnancies. The incidences of both gestational diabetes (5.6%) and gestational hypoglycaemia (3.9%) in twin pregnancies were more than double those in singleton pregnancies (2.5% and 1.7%, respectively) (P<0.01). As the risk of perinatal death is increased in these patients, glucose tolerance tests should be performed in all patients with twin pregnancies.