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Multicenter, Randomized, Double-Blind, Placebo-Controlled, Single-Ascending Dose Study of the Oral γ-Secretase Inhibitor BMS-708163 (Avagacestat): Tolerability Profile, Pharmacokinetic Parameters, and Pharmacodynamic Markers

Single-ascending Dose StudyTherapeutic Drug MonitoringPharmacologyClinical TrialsPharmacokinetic ParametersClinical PharmacologyDrug MonitoringPharmacotherapyMedicinePharmacokineticsPharmacodynamic ModelingTolerability Profile