Apparent maintenance of cytochrome P 450 by nicotinamide in primary cultures of rat hepatocytes

The Carbon Monoxide-binding Pigment of Liver Microsomes

Tsuneo Omura, Ryo Sato · Journal of Biological Chemistry · 1964 · 11.8K citations · Full text

Life Sciences, Biochemistry, Chemistry +8

Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.

James A. Miller · PubMed · 1970 · 1.5K citations

Medicine, Cancer Biology, Toxicology +10

Drug Metabolism in Adult Rat Hepatocytes in Primary Monolayer Culture

Philip S. Guzelian, D. Montgomery Bissell, Urs Meyer · Gastroenterology · 1977 · 227 citations

Pharmacy, Biochemistry, Pharmacology +15

A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity—I correlation of changes in covalent binding of reactivity metabolites with changes in the incidence and severity of toxicity

James R. Gillette · Biochemical Pharmacology · 1974 · 226 citations

Pharmacy, Chemistry, Toxicology +16

Maintenance of cytochrome P-450 and metabolism of aflatoxin B1 in primary hepatocyte cultures

Gary M. Decad, D.P.H. Hsieh, James L. Byard · Biochemical and Biophysical Research Communications · 1977 · 177 citations

Life Sciences, Biochemistry, Toxicology +15