Isothiourea‐Catalyzed Enantioselective Carboxy Group Transfer

Abstract

Transferable skills: Enantiomerically pure isothioureas promote the O- to C-carboxyl group transfer of oxazolyl carbonates with excellent levels of enantiocontrol (see scheme). The origin of the enantioselectivity of this process was probed mechanistically and rationalized computationally.