Concepedia

Can Expression of Apoptosis Genes, bcl-2 and bax, Predict Survival and Responsiveness to Chemotherapy in Node-Negative Breast Cancer Patients?

George D. Kymionis, C.E. Dimitrakakis, M.M. Konstadoulakis, Iordanis Arzimanoglou, Emmanuel Leandros, George Chalkiadakis, Antonios Keramopoulos, S. Michalas

Journal of Surgical Research · 2001 · 46 citations · 35 references

DOI

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References

35

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

Zoltán N. Oltval, Curt Milliman, Stanley J. Korsmeyer · Cell · 1993 · 6K citations

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Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.

Y Tsujimoto, Carlo M. Croce · Proceedings of the National Academy of Sciences · 1986 · 1.1K citations · Full text

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bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs.

Toshiyuki Miyashita, John C. Reed · PubMed · 1992 · 480 citations

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Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma.

Stanisław Krajewski, Carl Blomqvist, Kaarle Franssila et al. · PubMed · 1995 · 469 citations

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The Bcl-2 Protein: a Prognostic Indicator Strongly Related to p53 Protein in Lymph Node-Negative Breast Cancer Patients

R Silvestrini, Silvia Veneroni, Maria Grazia Daidone et al. · JNCI Journal of the National Cancer Institute · 1994 · 462 citations

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