Antibiotic Resistance of Isolated Gram Negative Bacteria From Urinary Tract Infections (UTIs) in Isfahan

Abstract

Background: Urinary tract infection (UTI) is a common bacterial disease which may cause chronic renal failure and hypertension. Many reports suggest that the rate of antibiotic resistance to infectious organisms is increasing. Objectives: This study aimed to detect and also compare the frequency and drug resistance pattern of Gram negative bacteria isolated from patients with community-acquired UTIs in Isfahan. Patients and Methods: In this cross-sectional descriptive study, 702 samples from 476 females and 226 males referred to medical centers in Isfahan city from June to September 2011 were collected, we investigated the urine cultures and antibiotic sensitivity of the isolated organisms were measured. Results: Urinary infectious was detected in 203 persons. The most prevalence isolated bacteria were Escherichiacoli 138 (68%), followed by Klebsiella spp. (13%). Antibiotic resistance pattern of Gram negative bacteria isolated was investigated. Among E. coli isolates the most antibiotic sensitivity and resistance were related to Nitrofurantoin, Cotrimoxazol and Nalidixic acid, Trimetsulpha respectively. Klebsiella spp. isolates were the most antibiotic sensitive to Cotrimoxazol and Cipropheloxacin and the most antibiotic resistant to Trimetsulpha, Cipropheloxacin and Nalidixic respectively. Conclusions: With regards to the continuous changing in causative microorganisms isolated from patients with UTI and antibiotic sensitivity patterns, it is recommended that bacterial sensitivity patterns in populations are determined in any region annually. .