Concepedia

Varenicline Is a Partial Agonist at α4β2 and a Full Agonist at α7 Neuronal Nicotinic Receptors

Karla B. Mihalak, F. Ivy Carroll, Charles W. Luetje

Molecular Pharmacology · 2006 · 556 citations · 22 references

DOI

Concepts

References

22

Varenicline:  An α4β2 Nicotinic Receptor Partial Agonist for Smoking Cessation

Jotham W. Coe, Paige R. Brooks, Michael G. Vetelino et al. · Journal of Medicinal Chemistry · 2005 · 933 citations · Full text

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Both alpha- and beta-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors

CW Luetje, James W. Patrick · Journal of Neuroscience · 1991 · 560 citations · Full text

, , +17

Subunit Composition and Pharmacology of Two Classes of Striatal Presynaptic Nicotinic Acetylcholine Receptors Mediating Dopamine Release in Mice

Outi Salminen, Karen L. Murphy, J. Michael McIntosh et al. · Molecular Pharmacology · 2004 · 405 citations

, , +17

Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes.

Laura E. Chavez-Noriega, James H. Crona, Mark Washburn et al. · PubMed · 1997 · 393 citations

, , +17

Partial agonist properties of cytisine on neuronal nicotinic receptors containing the beta 2 subunit.

Roger L. Papke, Steve Heinemann · Molecular Pharmacology · 1994 · 260 citations

, , +17