Concepedia

Local cytokine availability elicits tumor rejection and systemic immunity through granulocyte-T-lymphocyte cross-talk.

Mario P. Colombo, Andrea Modesti, Giorgio Parmiani, G Forni

PubMed · 1992 · 181 citations · 40 references

Concepts

Life SciencesImmunologyOncologyCancer ImmunologyCellular ImmunologyTumor ImmunologyAntitumor T Cell ResponsesCancer ImmunotherapyCell-mediated ImmunityCytokines In Tumor ImmunityTumor Immune MicroenvironmentTumor-infiltrating LymphocytesCytokine-mediated T Cell ActivationCytokine-mediated Tumor Microenvironment ModulationSystemic Immunity Against PathogensT-cell Responses To Tumor AntigensTumor-immune CrosstalkTumor-specific Cytokine Secretion By T Cells

References

40

Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response

Eric R. Fearon, Drew M. Pardoll, Toshiuki Itaya et al. · Cell · 1990 · 922 citations

Life Sciences, Immunology, Oncology +17

Murine interleukin-4 displays potent anti-tumor activity in vivo

Robert I. Tepper, Paul K. Pattengale, Philip Leder · Cell · 1989 · 780 citations

Medicine, Immunology, Oncology +10

Treatment of Established Renal Cancer by Tumor Cells Engineered to Secrete Interleukin-4

Paul T. Golumbek, Audrey J. Lazenby, Hyam I. Levitsky et al. · Science · 1991 · 731 citations

Medicine, Immunology, Oncology +17

Interleukin-8 gene expression by a pulmonary epithelial cell line. A model for cytokine networks in the lung.

T J Standiford, Steven L. Kunkel, A. BASHA et al. · Journal of Clinical Investigation · 1990 · 700 citations · Full text

Life Sciences, Cell Biology, Immunology +10

Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity.

Bernd Gänsbacher, Karen S. Zier, Brian Daniels et al. · The Journal of Experimental Medicine · 1990 · 624 citations · Full text

Medicine, Immunology, Oncology +15