Serum tumor necrosis factor-α levels and components of the metabolic syndrome in obese adolescents

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Gökhan S. Hotamışlıgil, Narinder S. Shargill, Bruce M. Spiegelman · Science · 1993 · 7.5K citations

Medicine, Endocrinology, Molecular Biology +17

Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study.

Helen B. Hubert, M Feinleib, Patricia McNamara et al. · Circulation · 1983 · 4.3K citations · Full text

Medicine, Cardiology, Epidemiology +16

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

Gökhan S. Hotamışlıgil, Pascal Peraldi, Adriane I. Budavari et al. · Science · 1996 · 2.6K citations

Life Sciences, Endocrinology, Molecular Biology +17

The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase.

Philip A. Kern, Mehrnoosh Saghizadeh, Juling Ong et al. · Journal of Clinical Investigation · 1995 · 1.3K citations · Full text

Life Sciences, Molecular Biology, Physiology +10

Tumor necrosis factor alpha inhibits signaling from the insulin receptor.

David Murray, Lisa Choy, Bruce M. Spiegelman · Proceedings of the National Academy of Sciences · 1994 · 1.2K citations · Full text

Life Sciences, Biochemistry, Endocrinology +17