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New pyrazolo[1,5a]pyrimidines as orally active inhibitors of Lck

Nina Gommermann, Peter Buehlmayer, Anette von Matt, Werner Breitenstein, Keiichi Masuya, Bernard Pirard, Pascal Furet, Sandra W. Cowan‐Jacob, Gisbert Weckbecker

Bioorganic & Medicinal Chemistry Letters · 2010 · 25 citations · 12 references

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12

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

David B. Straus · Cell · 1992 · 1K citations

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Profound block in thymocyte development in mice lacking p56lck

Thierry Jo Molina, Kenji Kishihara, David P. Siderovski et al. · Nature · 1992 · 966 citations

, , +9

MetaSite:  Understanding Metabolism in Human Cytochromes from the Perspective of the Chemist

Gabriele Cruciani, Emanuele Carosati, Benoît De Boeck et al. · Journal of Medicinal Chemistry · 2005 · 491 citations

, , +17

Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes.

Nicolai S. C. van Oers, Nigel Killeen, Arthur Weiss · The Journal of Experimental Medicine · 1996 · 332 citations · Full text

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Cytokine‐related syndrome following injection of anti‐CD3 monoclonal antibody: Further evidence for transient <i>in vivo</i> T cell activation

Christiane Ferran, Kathleen C. F. Sheehan, Michel Dy et al. · European Journal of Immunology · 1990 · 267 citations

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