Angewandte Chemie International Edition · 2012 · 39 citations · 23 references
Drug TargetBioorganic ChemistryGlycobiologyMedicinal ChemistryUnnatural Hexosamine MimicsCancer Cell BiologyAnti-cancer AgentCancer MetabolismFluorine AtomGlycosylationBiochemistryProstatic DiseaseDrug DevelopmentPharmacologyBiomolecular EngineeringEndocrine-related CancerNatural SciencesUnnatural SugarMetabolic PerturbationMedicineCarbohydrate-protein InteractionDrug DiscoveryDrug Analysis
Inhibited: N-acetylglucosamine (GlcNAc) derivatives with a fluorine atom at the C4 position (2-4) were synthesized, and their ability to inhibit cancer-cell growth was investigated. The administration of these 4F-GlcNAc derivatives to cells led to the unnatural sugar nucleotide 1. Furthermore, N-glycan profiles of cells were determined by using a glycoblotting-based enrichment analysis, which is suitable for high-throughput screenings for drug discovery.
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β1-6 Branching of Asn-Linked Oligosaccharides Is Directly Associated with Metastasis
James W. Dennis, Suzanne Laferté, Carol Waghorne et al. · Science · 1987 · 937 citations