A PROPOSAL FOR A UNIFORM NOMENCLATURE IN BACTERIAL GENETICS

TLDR

The proposal builds on earlier nomenclature systems developed with international collaborators and is designed to evolve as bacterial genetics advances. The authors aim to provide a flexible, widely available nomenclature that offers unique strain designations, typing convenience, and adaptability to future developments. The system is based on guiding principles that distinguish genotype symbols from phenotype abbreviations and supply a uniform set of symbols for loci, mutant alleles, and mutations. The system has proven convenient, enhancing laboratory communication and understanding, and its growing adoption demonstrates its practicality. Comments, suggestions, and additions are welcome.

Abstract

The current proposal is an outgrowth of its predecessors, developed by the present authors in consultation with colleagues in other laboratories and in other countries. The basic system has proven convenient to use in the laboratory and has greatly facilitated understanding and communication among many laboratories in the intervening years; increasing use of the system also speaks for its practicality. Thus this proposal does not intend to present a rigid, ‘official’, frozen system of nomenclature. The system is bound to evolve as knowledge advances in the future. The present communication is aimed at making widely available the proposal as developed to date. Comments, suggestions, and additions are welcome. The aims of the present proposal are: uniformity; a unique designation for each strain ; convenience for typing, editing, printing, record-keeping, and information retrieval ; and adaptability, simplicity, clarity, and comprehension by workers in all areas of biology; adaptability to new developments in the foreseeable future. The proposal takes the form of a set of guiding principles for dealing with categories where usage can be clearly defined; application to specific situations is left to each individual worker. The standardized system of genetic symbols is designed to serve the following purposes : (I) To distinguish clearly between symbols representing the genotype of a bacterial strain, and abbreviations of words which describe phenotypic properties. (2) To provide a uniform set of symbols for genetic loci, mutant alleles and mutation 1963).