Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

Paola Scaffidi, Tom Misteli, Marco E. Bianchi · Nature · 2002 · 4.1K citations

Inflammation, Chromatin, Cytokine +10

Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients

Munir Pirmohamed, Sally James, Shaun Meakin et al. · BMJ · 2004 · 3.2K citations · Full text

Association between presence of HLA-B*5701, HLA-DR7 , and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir

S. Mallal, David Nolan, Campbell S. Witt et al. · The Lancet · 2002 · 1.4K citations

Allergy, Human Retrovirus, Immunology +7

Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion

Tiziana Bonaldi · The EMBO Journal · 2003 · 1.2K citations · Full text

Chromatin, Protein Secretion, Cell Regulation +8

Timing of New Black Box Warnings and Withdrawals for Prescription Medications

Karen E. Lasser · JAMA · 2002 · 1K citations