Concepedia

Protein Engineering Strategies for Sustained Glucagon-Like Peptide-1 Receptor–Dependent Control of Glucose Homeostasis

Kristen Picha, Mark R. Cunningham, Daniel J. Drucker, Ashok Mathur, Tatiana Ort, Michael S. Scully, Avery R. Soderman, Tracy Spinka-Doms, V. Stojanovic‐Susulic, Beth Ann Thomas,

Diabetes · 2008 · 40 citations · 35 references

DOIFull text

Open access

Abstract

Taken together, our data demonstrate that CNTO736 produces a spectrum of GLP-1 receptor-dependent actions while exhibiting significantly improved pharmacokinetics relative to the native GLP-1 peptide.

References

35

A role for glucagon-like peptide-1 in the central regulation of feeding

Mandy D. Turton, Donal O’Shea, I. Gunn et al. · Nature · 1996 · 1.9K citations

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GLUCAGON-LIKE PEPTIDE-1 7-36: A PHYSIOLOGICAL INCRETIN IN MAN

Bernhard Kreymann, Mohammad A. Ghatei, Gareth Williams et al. · The Lancet · 1987 · 1.9K citations

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Effects of Exenatide (Exendin-4) on Glycemic Control and Weight Over 30 Weeks in Metformin-Treated Patients With Type 2 Diabetes

Ralph A. DeFronzo, Robert E. Ratner, Jenny Han et al. · Diabetes Care · 2005 · 1.5K citations

Effects of Exenatide (Exendin-4) on Glycemic Control Over 30 Weeks in Sulfonylurea-Treated Patients With Type 2 Diabetes

John B. Buse, Robert R. Henry, Jenny Han et al. · Diabetes Care · 2004 · 1.3K citations · Full text

Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and β-cell function in type 2 diabetes: a parallel-group study

Mette Zander, Sten Madsbad, Jan Lysgaard Madsen et al. · The Lancet · 2002 · 1.3K citations

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