Concepedia

miR-199a-5p Silencing Regulates the Unfolded Protein Response in Chronic Obstructive Pulmonary Disease and α <sub>1</sub> -Antitrypsin Deficiency

Tidi Hassan, Tomás P. Carroll, Patrick G. Buckley, Robert Cummins, Shane O’Neill, Noel G. McElvaney, Catherine M. Greene

American Journal of Respiratory and Critical Care Medicine · 2013 · 74 citations · 48 references

DOI

Abstract

miR-199a-5p is a key regulator of the unfolded protein response in AAT-deficient monocytes, and epigenetic silencing of its expression regulates this process in chronic obstructive pulmonary disease.

References

48

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Glen M. Borchert, William P. Lanier, Beverly L. Davidson · Nature Structural & Molecular Biology · 2006 · 1.4K citations

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