Conversion and degradation of [125I] labelled angiotensin I in isolated perfused porcine coronary and carotid arteries

Abstract

(1) Vascular angiotensin I to II conversion is not limited to the endothelial surface. (2) ACE is the most important, if not the only, enzyme responsible for vascular angiotensin I to II conversion. (3) If angiotensin I and II are formed in the adventitia or media, little of these peptides will enter the vascular lumen.