Src Family Kinase Activity Is Up-Regulated in Hormone-Refractory Prostate Cancer - Concepedia

Concepedia

Publication | Open Access

Src Family Kinase Activity Is Up-Regulated in Hormone-Refractory Prostate Cancer

DOI Full Paper Access

153

Citations

23

References

2009

Year

Oleg Tatarov, Thomas J. Mitchell, Morag Seywright, Hing Y. Leung, Valerie G. Brunton, Joanne Edwards

Clinical Cancer Research

Abstract

Appropriate patient selection may allow better targeting of prostate cancer patients who are likely to respond to the treatment with SFK inhibitors at the same time improving the outcome of clinical trials.

References

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Discovery of <i>N</i>-(2-Chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a Dual Src/Abl Kinase Inhibitor with Potent Antitumor Activity in Preclinical Assays Louis J. Lombardo, Francis Y. Lee, Ping Chen, Journal of Medicinal Chemistry Drug TargetPreclinical AssaysPharmacotherapyCompound 13Pharmaceutical Chemistry	2004	1.3K
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Androgen receptor gene amplification and protein expression in hormone refractory prostate cancer Joanne Edwards, N. Sarath Krishna, Ken Grigor, British Journal of Cancer	2003	426
Action of the Src Family Kinase Inhibitor, Dasatinib (BMS-354825), on Human Prostate Cancer Cells Sangkil Nam, Donghwa Kim, Jin Cheng, Cancer Research	2005	371
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Alterations in the focal adhesion kinase/Src signal transduction pathway correlate with increased migratory capacity of prostate carcinoma cells Jill K. Slack, Reid B. Adams, Joshua D. Rovin, Oncogene Signal TransductionPerineural InvasionCell RegulationSignaling PathwayReceptor Tyrosine Kinase	2001	198
Neuropeptide-Induced Androgen Independence in Prostate Cancer Cells: Roles of Nonreceptor Tyrosine Kinases Etk/Bmx, Src, and Focal Adhesion Kinase Li‐Fen Lee, Jun‐Lin Guan, Yun Qiu, Molecular and Cellular Biology GynecologyProstate Cancer CellsSignaling PathwayReceptor Tyrosine KinaseFocal Adhesion Kinase	2001	182

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