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14-3-3σ Modulates Pancreatic Cancer Cell Survival and Invasiveness

Divas Neupane, Murray Korc

Clinical Cancer Research · 2008 · 54 citations · 45 references

DOIFull text

Open access

Abstract

14-3-3sigma contributes to the chemoresistance of pancreatic cancer cells and exerts cell type-dependent effects on cell migration and invasion. Therefore, strategies aimed at suppressing 14-3-3sigma expression and function may have a therapeutic benefit in subgroups of patients with PDAC.

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