Concepedia

Prediction of Reinforcing Responses to Psychostimulants in Humans by Brain Dopamine D<sub>2</sub> Receptor Levels

Nora D. Volkow, Gene-Jack Wang, Joanna S. Fowler, Jean Logan, S. John Gatley, Andrew J. Gifford, Robert Hitzemann, Yu‐Shin Ding, Naomi Pappas

American Journal of Psychiatry · 1999 · 406 citations · 16 references

DOI

Abstract

These results provide preliminary evidence that D2 receptor levels predict response to psychostimulants in humans and that low D2 receptors may contribute to psychostimulant abuse by favoring pleasant response.

References

16

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Graphical Analysis of Reversible Radioligand Binding from Time—Activity Measurements Applied to [<i>N</i>-<sup>11</sup>C-Methyl]-(−)-Cocaine PET Studies in Human Subjects

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Harriet de Wit, Roy A. Wise · Canadian Journal of Psychology/Revue Canadienne de Psychologie · 1977 · 493 citations

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Absence of opiate rewarding effects in mice lacking dopamine D2 receptors

Rafael Maldonado, Adolfo Saiardi, Olga Valverde et al. · Nature · 1997 · 439 citations

, , +9