Chemistry - A European Journal · 2013 · 91 citations · 48 references
Natural SciencesChemistryCatalysisGreen ChemistryAmino Acid ChemistryCatalytic MechanismsOrganic SynthesisAmino Acid AnaloguesAmino Acid DerivativesEnantioselective CatalysisEnantioselective SynthesisProton Transfer ReactionsSubstrate ScopeSubstrate Scope ExpansionSubstrate Scope Screening
A green way to amino acids: α-Tetrasubstituted α-amino acid derivatives are formed in high yield and enantioselectivity by using a Rh-catalyzed enantioselective alkynylation of α-ketiminoesters. This reaction, which involves a proton transfer and can be conducted at room temperature, has high substrate scope (see scheme; Cbz = benzyloxycarbonyl, Fmoc = 9-fluorenylmethyloxycarbonyl).
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