Major attenuation of food reward with performance-sparing doses of pimozide in the rat.

Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain.

Peter Milner · Journal of Comparative and Physiological Psychology · 1954 · 3.1K citations

Positive Reinforcement, Neurobiological Mechanism, Electrical Stimulation +12

Antipsychotic Drugs: Direct Correlation Between Clinical Potency and Presynaptic Action on Dopamine Neurons

Philip Seeman, Teresa Lee · Science · 1975 · 867 citations

Blockade of cocaine reinforcement in rats with the dopamine receptor blocker pimozide, but not with the noradrenergic blockers phentolamine or phenoxybenzamine.

Harriet de Wit, Roy A. Wise · Canadian Journal of Psychology/Revue Canadienne de Psychologie · 1977 · 493 citations

Molecular Pharmacology, Cocaine Reinforcement, Psychiatry +13

Possible Etiology of Schizophrenia: Progressive Damage to the Noradrenergic Reward System by 6-Hydroxydopamine

Larry Stein, C. David Wise · Science · 1971 · 481 citations

Neuropsychology, Psychotropic Medication, Psychopharmacology +22

The pathogenesis of Parkinson's disease: a new hypothesis.

André Barbeau · PubMed · 1962 · 345 citations · Full text

New Hypothesis, Neurodegenerative Diseases, Motor Dysfunction +9