PTEN Lipid Phosphatase Activity and Proper Subcellular Localization Are Necessary and Sufficient for Down-Regulating AKT Phosphorylation in the Nucleus in Cowden Syndrome

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

Danny Liaw, Deborah J. Marsh, Jing Li et al. · Nature Genetics · 1997 · 2.1K citations

Thyroid Cancer Syndrome, Genetics, Pathology +4

Role of Translocation in the Activation and Function of Protein Kinase B

Mirjana Andjelković, Dario R. Alessi, Roger Meier et al. · Journal of Biological Chemistry · 1997 · 1.1K citations · Full text

Lifetime Cancer Risks in Individuals with Germline<i>PTEN</i>Mutations

Min-Han Tan, Jessica L. Mester, Joanne Ngeow et al. · Clinical Cancer Research · 2012 · 861 citations · Full text

Ubiquitination Regulates PTEN Nuclear Import and Tumor Suppression

Lloyd C. Trotman, Xinjiang Wang, Andrea Alimonti et al. · Cell · 2007 · 738 citations · Full text

Signaling Pathway, Cell Regulation, Cell Signaling +5

Immunohistochemical Evidence of Loss of PTEN Expression in Primary Ductal Adenocarcinomas of the Breast

Aurel Perren, Liang-Ping Weng, Alexander H. Boag et al. · American Journal Of Pathology · 1999 · 376 citations · Full text

Tumor Biology, Immunohistochemical Evidence, Breast Oncology +9